Increased Cardiovascular Mortality After Early Bilateral Oophorectomy (printer-friendly)
نویسندگان
چکیده
and Introduction
منابع مشابه
Bilateral oophorectomy, body mass index, and mortality in U.S. women aged 40 years and older.
Bilateral oophorectomy is used as a risk reduction strategy in BRCA1/2 mutation carriers, although data on long-term side effects are not yet available. In the general population, oophorectomy, particularly at a young age, has been associated with increased overall and cardiovascular disease (CVD) mortality. The mechanisms for this association are not well understood. We examined the associatio...
متن کاملIncreased mortality for neurological and mental diseases following early bilateral oophorectomy.
BACKGROUND The effects of oophorectomy on brain aging remain uncertain. METHODS We conducted a cohort study with long-term follow-up of women in Olmsted County, Minn., USA, who underwent either unilateral or bilateral oophorectomy before the onset of menopause from 1950 through 1987. Each member of the oophorectomy cohort was matched by age to a referent woman from the same population who had...
متن کاملRisk-reducing Surgery in Women at Risk for Familial Breast or Ovarian Cancer.
An estimated 5 % of breast cancers and 10 % of ovarian cancers may be due to inherited autosomal dominant breast and ovarian cancer alleles BRCA1 und BRCA2. According to population-based studies 1 or 2 women per 1000 carry such a risk allele. The cumulative cancer risk for healthy women with a BRCA-mutation is between 60 and 85 % for breast cancer and between 20 and 60 % for ovarian cancer. Rec...
متن کاملLong-term mortality associated with oophorectomy compared with ovarian conservation in the nurses' health study.
OBJECTIVE To report long-term mortality after oophorectomy or ovarian conservation at the time of hysterectomy in subgroups of women based on age at the time of surgery, use of estrogen therapy, presence of risk factors for coronary heart disease, and length of follow-up. METHODS This was a prospective cohort study of 30,117 Nurses' Health Study participants undergoing hysterectomy for benign...
متن کاملOvarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study.
OBJECTIVE To report long-term health outcomes and mortality after oophorectomy or ovarian conservation. METHODS We conducted a prospective, observational study of 29,380 women participants of the Nurses' Health Study who had a hysterectomy for benign disease; 16,345 (55.6%) had hysterectomy with bilateral oophorectomy, and 13,035 (44.4%) had hysterectomy with ovarian conservation. We evaluate...
متن کامل